Publications

Representative Publications

Banninger, G. and N.C. Reich (2004) STAT2 nuclear trafficking. J. Biol. Chem.. 279: 39199-206.

Gomez, D. and N.C. Reich, 2003. Stimulation of Primary Human Endothelial Cell Proliferation by IFN-alpha, J. Immunology 170: 5373-5381

McBride, K., G. Banninger, C. McDonald and N.C. Reich. 2002. Regulated nuclear import of the STAT1 transcription factor by direct binding to importin-a5, EMBO J., in press

Faruqi. T.R., D. Gomez, X. Bustelo, D. Bar-Sagi and N.C. Reich. 2001. Rac1 mediates STAT3 activation by autocrine IL-6. Proc Natl Acad Sci USA, 98:9014-9019

Weaver, B., O. Ando, K.P. Kumar and N.C. Reich. 2001. Apoptosis promoted by the dsRNA activated factor (DRAF1) during viral infection independent of the action of interferon or p53. FASEB J., 15:501-551

McBride, K.E., C. McDonald, and N.C. Reich. 2000. Nuclear export signal located within the DNA-binding domain of the STAT1 transcription factor. EMBO J. 19:6196-6206.

Kumar, K.P., K. McBride, B. Weaver, C. Dingwall, and N.C. Reich. 2000. Regulated nuclear-cytoplasmic localization of interferon regulatory factor-3 subunit of the dsRNA activated transcription factor, DRAF1. Mol. & Cell. Biol. 20:4159-4168.

McDonald, C. and N.C. Reich. 1999. Cooperation of the transcriptional coactivators CBP/p300 with STAT6. J. Interferon & Cytokine Res. 19:711-722.

Weaver, B.K., K.P. Kumar and N.C. Reich. 1998. Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 are Subunits of the dsRNA Activated Transcription Factor, DRAF1. Mol. & Cell. Biology 18:359-368.

Martinez-Moczygemba, M., M.J. Gutch, D. French and N.C. Reich. 1997. Distinct STAT Structure Promotes Interaction of STAT2 with the p48 Subunit of the Interferon-a Stimulated Transcription Factor, ISGF3. J. Biol. Chem. 272:200070-200076.

Kotanides, H. and N.C. Reich. 1996. Interleukin-4 Induced STAT6 Recognizes and Activates a Target Site in the Promoter of the Interleukin-4 Receptor Gene. J. Biol. Chem. 271:25555-25561.

Gilmour, K.C., R. Pine and N.C. Reich. 1995. Interleukin-2 Activates STAT5 (Mammary Gland Factor) and Specific Gene Expression in T Lymphocytes. Proc. Natl. Acad. Sci. USA 92:10772-10776.

Daly, C. and N.C. Reich. 1995. Characterization of dsRNA Activated Factors (DRAFs) as Positive Regulators of Interferon-a Stimulated Genes. J. Biol. Chem. 270:23739-23746.

Gilmour, K.C. and N.C. Reich. 1994. Receptor to Nucleus Signaling by Prolactin and Interleukin-2 Via Activation of Latent DNA-Binding Factors. Proc. Natl. Acad. Sci. USA 91:6850-6854.

Kotanides, H. and N.C. Reich. 1993. Tyrosine Phosphorylation is Required for Rapid Activation of a DNA-Binding Factor by Interleukin-4. Science 262:1265-1267.

Gutch, M.J., C. Daly, and N.C. Reich. 1992. Tyrosine Phosphorylation is Required for Activation of an a-Interferon Stimulated Transcription Factor. Proc. Natl. Acad. Sci. USA 89:11411-11415.

Reich, N.C., B. Evans, D. Levy, D. Fahey, E. Knight, Jr, and J.E. Darnell, Jr. 1987. Interferon-induced transcription of a gene encoding a 15kDa protein depends on an upstream enhancer element. Proc. Natl. Acad. Sci. USA 84:6394-6398.

Reich, N.C. and A.J. Levine. 1984. Growth regulation of a cellular tumor antigen, p53, in non-transformed cells. Nature 308:199-201.

Liu, L., K. McBride, and N.C. Reich. 2005. STAT3 import is independent of tyrosine phosphorylation and mediated by importin-a3, Proc Natl Acad Sci USA, 102:8150-8155.

Gilbert, M.M., B.K. Weaver, and N.C. Reich. 2005. A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation. Mech Development, 122: 939-948.

Reich, N.C. and L. Liu. 2006. Tracking STAT nuclear traffic, Nature Immunology Reviews, in press
Liu, L. Y. Gao, H. Qiu, W. T. Miller, V. Poli and N.C. Reich. 2006. Identification of STAT3 as a
specific substrate of Breast Tumor Kinase (Brk), Oncogene, in press

Cheng, TF., S. Brzostek, O. Ando, S. VanScoy, K.P. Kumar, and N.C. Reich. 2006. Differential
activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection. J.
Immunology 176:7462-7470.

Gilbert, M.M., B. Weaver, J. P. Gergen and N.C. Reich. 2005. A novel functional activator of the
Drosophila JAK/STAT pathway, Unpaired2, is revealed by an in vivo reporter of pathway
activation. Mech. of Development, 122: 939-948.

Liu, L., K. McBride and N.C. Reich. 2005. STAT3 Nuclear import is independent of tyrosine
phosphorylation and mediated by importin-a3. Proc. Natl. Acad. Sci USA, 7: 8150-8155.

McDonald, C., S. VanScoy, P. Hearing, and N.C. Reich. 2004. Induction of genes involved in cell
cycle progression by IL-4. J. Interferon & Cytokine Res., 24: 729-738.